Past Exam question - Worked example 1

Regarding paracetamol, which one of the following statements is true?
A it has significant anti-inflammatory activity
B it inhibits cyclo-oxygenase (Cox) 1 and 2
C it is excreted largely unchanged by the kidneys
D it can be given by intravenous infusion
E it is contraindicated in pregnancy

A FALSE - Paracetamol does not have anti-inflammatory activity. Paracetamol has anti-pyretic activity (reduces fever, and temperature control), and can help with pain (mechanism not clear). NSAIDs not paracetamol have anti-inflammatory activiy

B FALSE - Paracetamol does not inhibit cyclo-oxygenase (Cox) 1 and 2 - This is also the activity of NSAIDs, not paracetamol

C FALSE - Paracetamol is changed by the kidneys

D TRUE Paracetamol can be given by intravenous infusion.

E FALSE Paracetamol is safe in pregnancy.

If anyone wants more details on the answers please comment and I will try my best to answer in more detail.